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Article

Sir2 blocks extreme life-span extension.

Cell - 18 Nov 2005

Fabrizio Paola, Gattazzo Cristina, Battistella Luisa, Wei Min, Cheng Chao, McGrew Kristen, Longo Valter D

Abstract excerpt

Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span, and increasing Sir2 dosage can delay replicative aging. We address the role of Sir2 in regulating chronological life span in yeast. Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras...

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Identifiers

PMID: 16286010
DOI: 10.1016/j.cell.2005.08.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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