Article
Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
Nature - 5 Aug 2004
Wood Jason G, Rogina Blanka, Lavu Siva, Howitz Konrad, Helfand Stephen L, Tatar Marc, Sinclair David
Abstract excerpt
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis...
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