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Article

Calorie restriction reduces rDNA recombination independently of rDNA silencing.

Aging cell - 1 Dec 2009

Riesen Michèle, Morgan Alan

Abstract excerpt

Calorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD-dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination-ind...

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Share to Glucose
Share to DNA, Fungal
Share to DNA, Ribosomal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Gene Silencing

Share to Recombination, Genetic

Share to Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 19732046
DOI: 10.1111/j.1474-9726.2009.00514.x
PMCID: PMC2805862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19732046-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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