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Article

Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.

Cell cycle (Georgetown, Tex.) - 1 Aug 2006

Kawasaki Yosuke, Nagao Koji, Nakamura Takahiro, Yanagida Mitsuhiro

Abstract excerpt

Sister chromatid separation requires two steps of proteolysis. Securin, the chaperon and inhibitor of separase, is destructed in anaphase after polyubiquitination, and resulting activated separase cleaves the cohesin subunit Scc1/Rad21. Fission yeast securin/Cut2 and separase/Cut1 that form the complex are essential for viability and a number of temperature-sensitive (ts) mutants have been isolated. We here...

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Identifiers

PMID: 16861909
DOI: 10.4161/cc.5.16.3010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.PMID 16861909Read ↗

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