Article
A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability.
Development (Cambridge, England) - 1 Mar 2010
Wu Shuang, Scheible Wolf-Rüdiger, Schindelasch Dana, Van Den Daele Hilde, De Veylder Lieven, Baskin Tobias I
Abstract excerpt
The caspase family protease, separase, is required at anaphase onset to cleave the cohesin complex, which joins sister chromatids. However, among eukaryotes, separases have acquired novel functions. Here, we show that Arabidopsis thaliana radially swollen 4 (rsw4), a temperature-sensitive mutant isolated previously on the basis of root swelling, harbors a mutation in At4g22970, the A. thaliana separase. Loss of...
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