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Article

Studies on substrate recognition by the budding yeast separase.

The Journal of biological chemistry - 9 Jan 2004

Sullivan Matt, Hornig Nadine C D, Porstmann Thomas, Uhlmann Frank

Abstract excerpt

Sister chromatid cohesion is resolved at anaphase onset when separase, a site-specific protease, cleaves the Scc1 subunit of the chromosomal cohesin complex that is responsible for holding sister chromatids together. This mechanism to initiate anaphase is conserved in eukaryotes from budding yeast to man. Budding yeast separase recognizes and cleaves two conserved peptide motifs within Scc1. In addition, separase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14585836
DOI: 10.1074/jbc.M309761200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Studies on substrate recognition by the budding yeast separase.PMID 14585836Read ↗

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