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Article

Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.

International journal of biological macromolecules - 1 Mar 2026

Zhang Ke, Guo Shuchen, Sun Li, Hou Haitong, Watanabe Yoshinori

Abstract excerpt

Accurate chromosome segregation during mitosis and meiosis depends on shugoshin protein which localizes at the centromere of chromosomes. Sgo1, a meiosis-specific shugoshin in fission yeast, collaborates with the PP2A phosphatase enzyme to remove phosphate groups from Rec8 cohesin, thereby preventing its cleavage by separase during meiosis. Here we demonstrate that ectopic expression of Sgo1 causes chromosome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41786187
DOI: 10.1016/j.ijbiomac.2026.151175

Genes

APC
CDC20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.PMID 41786187Read ↗

Structure and function of the PP2A-shugoshin interaction.Semantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Semantic proximity Read ↗

D-box is required for the degradation of human Shugoshin and chromosome alignment.Semantic proximity Read ↗

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.Semantic proximity Read ↗

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassemblySemantic proximity Read ↗

A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions.Semantic proximity Read ↗

Meiotic shugoshins differ from mitotic ones by arginine-reach C-terminal motif in yeast, plant, animals, and humanSemantic proximity Read ↗

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae.Semantic proximity Read ↗

Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis.Semantic proximity Read ↗

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