Article
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Genes & development - 15 Mar 2009
Clift Dean, Bizzari Farid, Marston Adele L
Abstract excerpt
Chromosome segregation is triggered by separase, an enzyme that cleaves cohesin, the protein complex that holds sister chromatids together. Separase activation requires the destruction of its inhibitor, securin, which occurs only upon the correct attachment of chromosomes to the spindle. However, other mechanisms restrict separase activity to the appropriate window in the cell cycle because cohesin is cleaved in...
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