Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.

Abstract excerpt

Separase, the cysteine protease that cleaves cohesin and thereby triggers chromosome disjunction, is inhibited by both securin- and phosphorylation-dependent cyclin B1 binding. Using a novel phosphorylation-specific antibody, we show that mitotic-specific phosphorylation of human separase on S1126 is required to establish, but not maintain, cyclin B1 binding. Cells expressing a non-phosphorylatable S1126A mutant...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Securin
• Share to Aurora Kinase B
• Share to Aurora Kinases