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Elucidation of novel budding yeast separase mutants.

Bioscience, biotechnology, and biochemistry - 1 Jan 2016

Shimizu Yoshihito, Nagai Masayoshi, Yeasmin Akter M S T, Koike Naoki, Talukdar Muhammad Waliullah, Ushimaru Takashi

Abstract excerpt

The mitotic separase cleaves Scc1 in cohesin to allow sister chromatids to separate from each other upon anaphase onset. Separase is also required for DNA damage repair. Here, we isolated and characterized 10 temperature-sensitive (ts) mutants of separase ESP1 in the budding yeast Saccharomyces cerevisiae. All mutants were defective in sister chromatid separation at the restricted temperature. Some esp1-ts...

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Benomyl
Bleomycin
Green Fluorescent Proteins
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Osmotic Pressure

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Saccharomyces cerevisiae

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PMID: 26523765
DOI: 10.1080/09168451.2015.1101337

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