Article
Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.
Molecular biology of the cell - 1 May 2009
Chiroli Elena, Rancati Giulia, Catusi Ilaria, Lucchini Giovanna, Piatti Simonetta
Abstract excerpt
The spindle assembly checkpoint (SAC) is an evolutionarily conserved surveillance mechanism that delays anaphase onset and mitotic exit in response to the lack of kinetochore attachment. The target of the SAC is the E3 ubiquitin ligase anaphase-promoting complex (APC) bound to its Cdc20 activator. The Cdc20/APC complex is in turn required for sister chromatid separation and mitotic exit through ubiquitin-mediated...
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