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Article

Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2006

Nagao Koji, Yanagida Mitsuhiro

Abstract excerpt

Securin-separase complex is required for sister chromatid separation. Securin degrades in an APC/cyclosome dependent manner. Separase is activated on the destruction of securin and cleaves cohesin. Fission yeast securin/Cut2 required for proper separase localization has the motifs for destruction and separase-binding at the N- and C-termini, respectively. We report here the third essential domain, which becomes...

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Identifiers

PMID: 16483313
DOI: 10.1111/j.1365-2443.2006.00941.x

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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