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Article

Separase-mediated cleavage of cohesin at interphase is required for DNA repair.

Nature - 26 Aug 2004

Nagao Koji, Adachi Yoh, Yanagida Mitsuhiro

Abstract excerpt

Sister chromatids are held together by cohesins. At anaphase, separase is activated by degradation of its inhibitory partner, securin. Separase then cleaves cohesins, thus allowing sister chromatid separation. Fission yeast securin (Cut2) has destruction boxes and a separase (Cut1) interaction site in the amino and carboxyl terminus, respectively. Here we show that securin is essential for separase stability and...

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Identifiers

PMID: 15329725
DOI: 10.1038/nature02803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Separase-mediated cleavage of cohesin at interphase is required for DNA repair.PMID 15329725Read ↗

Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase.Semantic proximity Read ↗

Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.Semantic proximity Read ↗

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.Semantic proximity Read ↗

Elucidation of novel budding yeast separase mutants.Semantic proximity Read ↗

Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.Semantic proximity Read ↗

The Saccharomyces cerevisiae PDS1 and RAD9 checkpoint genes control different DNA double-strand break repair pathways.Semantic proximity Read ↗

Cdc48 is required for the stability of Cut1/separase in mitotic anaphase.Semantic proximity Read ↗

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.Semantic proximity Read ↗

Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin.Semantic proximity Read ↗

Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Semantic proximity Read ↗

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.Semantic proximity Read ↗

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis ISemantic proximity Read ↗

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