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Article

Cdc48 is required for the stability of Cut1/separase in mitotic anaphase.

Journal of structural biology - 1 Oct 2006

Ikai Nobuyasu, Yanagida Mitsuhiro

Abstract excerpt

Separase, a large protease essential for sister chromatid separation, cleaves the cohesin subunit Scc1/Rad21 during anaphase and leads to dissociation of the link between sister chromatids. Securin, a chaperone and inhibitor of separase, is ubiquitinated by APC/cyclosome, and degraded by 26S proteasome in anaphase. Cdc48/VCP/p97, an AAA ATPase, is involved in a variety of cellular activities, many of which are...

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Source

Identifiers

PMID: 16904908
DOI: 10.1016/j.jsb.2006.04.003

Genes

APC
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdc48 is required for the stability of Cut1/separase in mitotic anaphase.PMID 16904908Read ↗

Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.Semantic proximity Read ↗

Elucidation of novel budding yeast separase mutants.Semantic proximity Read ↗

A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.Semantic proximity Read ↗

Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase.Semantic proximity Read ↗

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis.Semantic proximity Read ↗

Studies on substrate recognition by the budding yeast separase.Semantic proximity Read ↗

Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.Semantic proximity Read ↗

Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses.Semantic proximity Read ↗

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.Semantic proximity Read ↗

Separase-mediated cleavage of cohesin at interphase is required for DNA repair.Semantic proximity Read ↗

Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation.Semantic proximity Read ↗

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