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A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2003

Matsumura Takuhiro, Yuasa Tatsuro, Hayashi Takeshi, Obara Takayuki, Kimata Yuu, Yanagida Mitsuhiro

Abstract excerpt

BACKGROUND: The fission yeast Schizosaccharomyces pombe separase/Cut1 and securin/Cut2 are required for anaphase-specific activation of proteolysis that leads to proper sister chromatid separation. We intended to identify ts (temperature sensitive) strains whose growth was inhibited by multicopy plasmid pCUT1 or pCUT2 at the permissive temperature. RESULTS: After a one-by-one transformation of 1015 randomly...

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PMID: 12653962
DOI: 10.1046/j.1365-2443.2003.00637.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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