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Article

Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer.

The Journal of pathology - 1 Oct 2006

Ogino S, Kawasaki T, Kirkner G J, Ogawa A, Dorfman I, Loda M, Fuchs C S

Abstract excerpt

p21 (CDKN1A/CIP1/WAF1), one of the cyclin-dependent kinase inhibitors, plays a key role in regulating the cell cycle and is transcriptionally regulated by p53. Down-regulation of p21 is caused by TP53 mutations in colorectal cancer. CpG island methylator phenotype (CIMP) appears to be a distinct subtype of colorectal cancer with concordant methylation of multiple gene promoters and is associated with a high...

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Source

Identifiers

PMID: 16850502
DOI: 10.1002/path.2030

Genes

BRAF
KRAS
CRABP1
MLH1
NEUROG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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