Article
Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Neoplasia (New York, N.Y.) - 1 Jun 2006
Ogino Shuji, Brahmandam Mohan, Kawasaki Takako, Kirkner Gregory J, Loda Massimo, Fuchs Charles S
Abstract excerpt
Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability-high (MSI-H) and CpG island methylator phenotype (CIMP) characterized by extensive promoter methylation, is associated with MSI-H. However, no studies have comprehensively examined interrelations between COX-2, p53, MSI, and CIMP. Using MethyLight, we measured DNA...
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