Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.

doi:10.1002/path.2879

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.

The Journal of pathology - 1 Nov 2011

Zlobec Inti, Bihl Michel, Foerster Anja, Rufle Alex, Lugli Alessandro

Abstract excerpt

CpG island methylator phenotype (CIMP) is being investigated for its role in the molecular and prognostic classification of colorectal cancer patients but is also emerging as a factor with the potential to influence clinical decision-making. We report a comprehensive analysis of clinico-pathological and molecular features (KRAS, BRAF and microsatellite instability, MSI) as well as of selected tumour- and...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
CDX2 Transcription Factor
Colorectal Neoplasms
CpG Islands
DNA Methylation
DNA, Neoplasm
Female
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lymphocytes, Tumor-Infiltrating

Male

Microsatellite Instability

Middle Aged

Mutation

Neoplasm Proteins

Source

Open in PubMed

Identifiers

PMID: 21660972
DOI: 10.1002/path.2879

Genes

BRAF
KRAS
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21660972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.PMID 21660972Read ↗

Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer.Semantic proximity Read ↗

Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer.Semantic proximity Read ↗

Meta-Analysis of the Prognostic and Predictive Role of the CpG Island Methylator Phenotype in Colorectal Cancer.Semantic proximity Read ↗

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status.Semantic proximity Read ↗

Toward a comprehensive and systematic methylome signature in colorectal cancersSemantic proximity Read ↗

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.Semantic proximity Read ↗

The methylation of <i>SDC2</i> and <i>TFPI2</i> defined three methylator phenotypes of colorectal cancerSemantic proximity Read ↗

The CpG island methylator phenotype in colorectal cancer: progress and problems.Semantic proximity Read ↗

Epigenetic alterations in colorectal cancer: the CpG island methylator phenotype.Semantic proximity Read ↗

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.Semantic proximity Read ↗

Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype.Semantic proximity Read ↗

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.