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Article

Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype.

Histopathology - 1 Nov 2008

Nosho K, Kawasaki T, Chan A T, Ohnishi M, Suemoto Y, Kirkner G J, Fuchs C S, Ogino S

Abstract excerpt

AIMS: Cyclin D1 and cyclin-dependent kinases are commonly activated in colorectal cancer. Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular classifiers in colorectal cancer. The aim was to clarify the relationship between cyclin D1, MSI and CIMP. METHODS AND RESULTS: Among 865 colorectal cancers with MSI and CIMP data, 246 tumours (28.4%) showed cyclin D1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclin-Dependent Kinase Inhibitor p21

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 18983468
DOI: 10.1111/j.1365-2559.2008.03161.x
PMCID: PMC2719983

Genes

BRAF
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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