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Article

Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2007

Ogino Shuji, Kawasaki Takako, Kirkner Gregory J, Yamaji Taiki, Loda Massimo, Fuchs Charles S

Abstract excerpt

Downregulation of p27 (cyclin-dependent kinase inhibitor-1B, CDKN1B or KIP1) is caused by increased ubiquitin-mediated proteasomal degradation in colorectal cancer, and has been associated with poor prognosis. CpG island methylator phenotype (CIMP) is a phenotype of colorectal cancer with extensive promoter methylation, and associated with high degree of microsatellite instability (MSI-H) and BRAF mutations. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17086168
DOI: 10.1038/modpathol.3800709

Genes

BRAF
CRABP1
KRAS
MLH1
NEUROG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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