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Article

Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma.

The American journal of surgical pathology - 1 Sept 2006

Ogino Shuji, Odze Robert D, Kawasaki Takako, Brahmandam Mohan, Kirkner Gregory J, Laird Peter W, Loda Massimo, Fuchs Charles S

Abstract excerpt

Extensive gene promoter methylation in colorectal carcinoma has been termed the CpG island methylator phenotype (CIMP). Previous studies on CIMP used primarily methylation-specific polymerase chain reaction (PCR), which, unfortunately, may detect low levels of methylation that has little or no biological significance. Utilizing quantitative real-time PCR (MethyLight), we measured DNA methylation in a panel of 5...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16931963
DOI: 10.1097/01.pas.0000213266.84725.d0

Genes

CRABP1
MLH1
NEUROG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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