Article
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.
Gut - 1 Jan 2009
Ogino Shuji, Nosho Katsuhiko, Kirkner Gregory J, Kawasaki Takako, Meyerhardt Jeffrey A, Loda Massimo, Giovannucci Edward L, Fuchs Charles S
Abstract excerpt
BACKGROUND: The CpG island methylator phenotype (CIMP), characterised by widespread promoter methylation, is associated with microsatellite instability (MSI) and BRAF mutation in colorectal cancer. The independent effect of CIMP, MSI and BRAF mutation on prognosis remains uncertain. METHODS: Util...
Topics
- Aged
- Colonic Neoplasms
- CpG Islands
- DNA Methylation
- DNA, Neoplasm
- Epidemiologic Methods
- Epigenesis, Genetic
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Mutation
- Neoplasm Staging
- Phenotype