Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.

International journal of cancer - 15 Jun 2008

Ogino Shuji, Kawasaki Takako, Nosho Katsuhiko, Ohnishi Mutsuko, Suemoto Yuko, Kirkner Gregory J, Fuchs Charles S

Abstract excerpt

The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DNA methylation level and methylation in individual CpG islands remains uncertain. Utilizing 869...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Genomic Instability

Share to Immunohistochemistry

Share to Long Interspersed Nucleotide Elements

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 18366060
DOI: 10.1002/ijc.23470
PMCID: PMC2630175

Genes

BRAF
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.PMID 18366060Read ↗

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.Semantic proximity Read ↗

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.Semantic proximity Read ↗

CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations.Semantic proximity Read ↗

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.Semantic proximity Read ↗

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status.Semantic proximity Read ↗

18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high.Semantic proximity Read ↗

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.Semantic proximity Read ↗

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.Semantic proximity Read ↗

Genome-scale analysis of aberrant DNA methylation in colorectal cancer.Semantic proximity Read ↗

Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases.Semantic proximity Read ↗

Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype.Semantic proximity Read ↗

The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.