Article
Mutations in the p53 gene in primary human breast cancers.
Cancer research - 15 Nov 1991
Osborne R J, Merlo G R, Mitsudomi T, Venesio T, Liscia D S, Cappa A P, Chiba I, Takahashi T, Nau M M, Callahan R
Abstract excerpt
Twenty-six primary breast tumors were examined for mutations in the p53 tumor suppressor gene by an RNase protection assay and nucleotide sequence analysis of PCR-amplified p53 complementary DNAs. Each method detected p53 mutations in the same three tumors (12%). One tumor contained two mutations...
Topics
- Base Sequence
- Breast Neoplasms
- Chromosome Mapping
- DNA, Neoplasm
- Female
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- RNA, Neoplasm