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Article

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.

Oncogene - 1 Mar 1991

Varley J M, Brammar W J, Lane D P, Swallow J E, Dolan C, Walker R A

Abstract excerpt

DNAs from ninety seven primary breast carcinoma biopsies have been examined for loss of sequences on 17p13. In addition, immunohistochemical analysis has been carried out on the majority of these cases to determine whether p53 gene expression can be detected. Detection of p53 expression is taken to indicate mutation of p53 leading to stabilisation of the protein and thus detectable levels of p53 in the cell. In...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Breast Neoplasms
Chromosomes, Human, Pair 17
Electrophoresis, Agar Gel
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Polymerase Chain Reaction

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 2011397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2011397-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.PMID 2011397Read ↗

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