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Article

p53 alterations in human squamous cell carcinomas and carcinoma cell lines.

The American journal of pathology - 1 Apr 1993

Caamano J, Zhang S Y, Rosvold E A, Bauer B, Klein-Szanto A J

Abstract excerpt

p53 alterations were studied in a group of 22 primary squamous cell carcinomas (SCC) of the head and neck and in 10 cell lines derived from SCC. Positive immunohistochemical detection of p53 was accomplished in 10 of 22 primary tumors and in 7 of 10 SCC cell lines. Loss of heterozygosity of chromosome 17p, were the p53 gene is localized, was seen in five of seven SCC lines studied. DNA sequencing of the p53 gene...

Topics

Carcinoma
Carcinoma, Squamous Cell
Codon
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Immunohistochemistry
Mutation
Polymerase Chain Reaction
Staining and Labeling
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7682763
PMCID: PMC1886889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7682763-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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