Article
p53 abnormalities and genomic instability in primary human breast carcinomas.
Cancer research - 1 Feb 1995
Eyfjörd J E, Thorlacius S, Steinarsdottir M, Valgardsdottir R, Ogmundsdottir H M, Anamthawat-Jonsson K
Abstract excerpt
Abnormalities in the p53 tumor suppressor gene have been shown to affect cell cycle control and lead to genetic instability in cell lines of murine and human origin. We have examined genetic instability in 183 primary human breast carcinomas with and without p53 abnormalities. Mutation analysis w...
Topics
- Breast Neoplasms
- Cell Cycle
- Chromosome Deletion
- DNA, Neoplasm
- Gene Amplification
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Karyotyping
- Metaphase
- Mutation
- Neoplasm Invasiveness
- Polymerase Chain Reaction
- Staining and Labeling
- Tumor Suppressor Protein p53