Article
Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.
Oncogene - 1 Oct 1990
Prosser J, Thompson A M, Cranston G, Evans H J
Abstract excerpt
Using the polymerase chain reaction, we have amplified exons 5 and 6 of the human p53 gene from paired samples of tumour and blood DNA of 60 patients with sporadic breast tumours and from placental or tonsil DNA of 30 normal controls. The patients' DNAs were previously examined for loss of heterozygosity of markers distal to the p53 gene on chromosome 17p and tumour samples were assayed for p53 mRNA levels....
Topics
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Codon
- DNA
- DNA, Neoplasm
- Exons
- Female
- Genes, Suppressor
- Humans
- Molecular Sequence Data
- Mutation