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Article

p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases.

Cancer genetics and cytogenetics - 1 Jul 1994

Seruca R, David L, Castedo S, Veiga I, Børresen A L, Sobrinho-Simões M

Abstract excerpt

We have looked for LOH, mutation, and expression of p53 in a series of 56 primary gastric carcinomas, using Southern blotting, constant denaturant gel electrophoresis (CDGE), direct sequencing, and immunohistochemistry. Two hundred-four lymph node metastases from 36 of these cases were also studied by immunohistochemistry. Loss of constitutional heterozygosity for the p53 locus was detected in five of 16...

Topics

Adult
Aged
DNA, Neoplasm
Female
Flow Cytometry
Genes, p53
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Tumor Cells, Cultured

Source

Identifiers

PMID: 8039163
DOI: 10.1016/0165-4608(94)90214-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8039163-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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