Genetic basis for p53 overexpression in human breast cancer.

doi:10.1073/pnas.88.11.5006

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Article

Genetic basis for p53 overexpression in human breast cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1991

Davidoff A M, Humphrey P A, Iglehart J D, Marks J R

Abstract excerpt

Overexpression of an activated form of the p53 protein may be involved in neoplastic transformation. We found widespread overexpression of p53 by immunohistochemical staining in 11 (22%) of 49 primary invasive human breast cancers. Northern blot analysis showed that this overexpression was not due to an increase in the steady-state level of p53 mRNA. The p53 gene was directly sequenced in 7 of these tumors with...

Topics

Alleles
Base Sequence
Blotting, Northern
Blotting, Southern
Breast Neoplasms
Chromosome Deletion
DNA, Neoplasm
Female
Gene Expression
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligonucleotide Probes

RNA, Messenger

RNA, Neoplasm

Restriction Mapping

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 2052583
DOI: 10.1073/pnas.88.11.5006
PMCID: PMC51796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2052583-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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