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Article

Genetic basis for p53 overexpression in human breast cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1991

Davidoff A M, Humphrey P A, Iglehart J D, Marks J R

Abstract excerpt

Overexpression of an activated form of the p53 protein may be involved in neoplastic transformation. We found widespread overexpression of p53 by immunohistochemical staining in 11 (22%) of 49 primary invasive human breast cancers. Northern blot analysis showed that this overexpression was not due to an increase in the steady-state level of p53 mRNA. The p53 gene was directly sequenced in 7 of these tumors with...

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Identifiers

PMID: 2052583
DOI: 10.1073/pnas.88.11.5006
PMCID: PMC51796

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