Article
p53 gene mutations and steroid receptor status in breast cancer. Clinicopathologic correlations and prognostic assessment.
Cancer - 15 Apr 1994
Caleffi M, Teague M W, Jensen R A, Vnencak-Jones C L, Dupont W D, Parl F F
Abstract excerpt
BACKGROUND: There is increasing evidence linking development and progression of cancer to an accumulation of mutations at the genomic level. The most frequently mutated gene known to date in sporadic breast cancer appears to be the tumor suppressor gene p53. This study was designed to determine the frequency of p53 gene mutations in primary breast cancer, to correlate the presence of p53 mutations with...
Topics
- Base Sequence
- Breast Neoplasms
- DNA, Neoplasm
- Electrophoresis
- Exons
- Female
- Follow-Up Studies
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasms, Hormone-Dependent