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Article

Tissue-specific sensitivity to AID expression in transgenic mouse models.

Gene - 1 Aug 2006

Rucci Francesca, Cattaneo Leonardo, Marrella Veronica, Sacco Maria Grazia, Sobacchi Cristina, Lucchini Franco, Nicola Stefania, Della Bella Silvia, Villa Maria Luisa, Imberti Luisa, Gentili Francesca, Montagna Cristina, Tiveron Cecilia, Tatangelo Laura, Facchetti Fabio, Vezzoni Paolo, Villa Anna

Abstract excerpt

Activation-induced cytidine deaminase (AID), an enzyme with homology to members of the APOBEC family, is involved in somatic hypermutation (SHM) of immunoglobulin (Ig) genes, either by direct deamination of DNA or by an indirect action through its putative RNA editing activity. AID is able to mutate both Ig-like reporter constructs and selected non-Ig genes in normal B cells and in other cells when ectopically...

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Identifiers

PMID: 16787714
DOI: 10.1016/j.gene.2006.03.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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