Article
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005
Kotani Ai, Okazaki Il-Mi, Muramatsu Masamichi, Kinoshita Kazuo, Begum Nasim A, Nakajima Toshiharu, Saito Hirohisa, Honjo Tasuku
Abstract excerpt
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutations (SHM) and class switch recombination. Overexpression of AID in non-B cells can induce SHM in artificial constructs inserted in various loci in the genome. AID overexpression was thus proposed to introduce mutations in a wide variety of genes with little specificity. We previously showed that AID transgenic mice developed T cell...
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