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Article

Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.

International journal of cancer - 15 Dec 2008

Morisawa Toshiyuki, Marusawa Hiroyuki, Ueda Yoshihide, Iwai Akio, Okazaki Il-mi, Honjo Tasuku, Chiba Tsutomu

Abstract excerpt

Various molecular changes characterizing organ-specific carcinogenesis have been identified in human tumors; however, the molecular mechanisms of the genomic changes specific for each cancer are not well defined. A transgenic (Tg) mouse model with constitutive expression of the nucleotide-editing enzyme, activation-induced cytidine deaminase (AID), develops tumors in various organs as a result of the mutagenic...

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Identifiers

PMID: 18781563
DOI: 10.1002/ijc.23853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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