Article
Uncoupling between Ig somatic hypermutation and oncogene mutation in mouse lymphoma.
Biochimica et biophysica acta - 1 Feb 2009
Vincent Christelle, Truffinet Véronique, Fiancette Remi, Petit Barbara, Cogné Nadine, Cogné Michel, Denizot Yves
Abstract excerpt
Burkitt lymphoma (BL) features translocations linking c-myc to the immunoglobulin heavy chain (IgH) locus. By inserting a c-myc gene under the control of the 3'IgH locus control region (LCR) into the mouse genome, we generated c-myc-3'LCR mice that develop clonal BL or diffuse anaplastic lymphoma. We show in the present study that while BL from c-myc-3'LCR mice would be classified as pre-germinal center (GC)...
Topics
- 5' Flanking Region
- Animals
- Burkitt Lymphoma
- DNA Mutational Analysis
- DNA-Binding Proteins
- Exons
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Locus Control Region
- Lymphoma