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Article

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity.

Tumour virus research - 1 Dec 2024

Šenigl Filip, Soikkeli Anni I, Prost Salomé, Schatz David G, Slavková Martina, Hejnar Jiří, Alinikula Jukka

Abstract excerpt

Simian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas. A related Merkel cell polyomavirus causes carcinoma in humans by expressing truncated large tumor antigen (LT), with truncations caused by APOBEC family of cytidine deaminase-induced mutations. AID (activation-induced cytidine deaminase), a member of the APOBEC...

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AICDA (Activation-Induced Cytidine Deaminase)
Antigens, Polyomavirus Transforming
Antigens, Viral, Tumor
Cytidine Deaminase
Polyomavirus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simian virus 40

Somatic Hypermutation, Immunoglobulin

Tumor Virus Infections

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Identifiers

PMID: 39490533
DOI: 10.1016/j.tvr.2024.200293
PMCID: PMC11564006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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