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Article

Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.

Molecular immunology - 1 Apr 2008

Shen Hong Ming, Bozek Grazyna, Pinkert Carl A, McBride Kevin, Wang Lili, Kenter Amy, Storb Ursula

Abstract excerpt

Activation-induced DNA cytidine deaminase (AID) is required for somatic hypermutation (SHM) and efficient class switch recombination (CSR) of immunoglobulin (Ig) genes. We created AID-transgenic mice that express AID ubiquitously under the control of a beta-actin promoter. When crossed with AID-/- mice, the AID-transgenic,AID-/- mice carried out SHM and CSR, showing that the AID transgenes were functional....

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18067961
DOI: 10.1016/j.molimm.2007.10.041
PMCID: PMC2376253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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