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Article

Constitutive Expression of AID Leads to Tumorigenesis

5 May 2003

Abstract excerpt

Genome stability is regulated by the balance between efficiencies of the repair machinery and genetic alterations such as mutations and chromosomal rearrangements. It has been postulated that deregulation of class switch recombination (CSR) and somatic hypermutation (SHM), which modify the immunoglobulin (Ig) genes in activated B cells, may be responsible for aberrant chromosomal translocations and mutations of...

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PMID: 12732658
DOI: 10.1084/jem.20030275

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