Article
Aberrant expression and mutation-inducing activity of AID in human lung cancer.
Annals of surgical oncology - 1 Jul 2011
Shinmura Kazuya, Igarashi Hisaki, Goto Masanori, Tao Hong, Yamada Hidetaka, Matsuura Shun, Tajima Mari, Matsuda Tomonari, Yamane Arito, Funai Kazuhito, Tanahashi Masayuki, Niwa Hiroshi, Ogawa Hiroshi, Sugimura Haruhiko
Abstract excerpt
BACKGROUND: Activation-induced cytidine deaminase (AID) is expressed in B lymphocytes and triggers antibody diversification. Recent reports have indicated that the constitutive expression of AID in mice causes not only lymphomas, but also cancers of some organs including the lung, prompting us to investigate the expression and effect of AID on human lung cancer. MATERIALS AND METHODS: We examined AID mRNA...
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