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Article

Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2007

Kotani Ai, Kakazu Naoki, Tsuruyama Tatsuaki, Okazaki Il-mi, Muramatsu Masamichi, Kinoshita Kazuo, Nagaoka Hitoshi, Yabe Daisuke, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID), which is essential to both class switch recombination and somatic hypermutation of the Ig gene, is expressed in many types of human B cell lymphoma/leukemia. AID is a potent mutator because it is involved in DNA breakage not only of Ig but also of other genes, including proto-oncogenes. Recent studies suggest that AID is required for chromosomal translocation involving...

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Identifiers

PMID: 17251349
DOI: 10.1073/pnas.0610732104
PMCID: PMC1785248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.PMID 17251349Read ↗

AID expression levels determine the extent of <i>cMyc</i> oncogenic translocations and the incidence of B cell tumor developmentSemantic proximity Read ↗

Activation-induced Cytidine Deaminase in B Cell Immunity and CancersSemantic proximity Read ↗

AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice.Semantic proximity Read ↗

Constitutive Expression of AID Leads to TumorigenesisSemantic proximity Read ↗

Epigenetic Function of Activation-Induced Cytidine Deaminase and Its Link to LymphomagenesisSemantic proximity Read ↗

Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in <i>BCR-ABL1</i> –Driven B-Cell Lineage Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

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