AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.

doi:10.1182/blood.2020008654

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Article

AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.

Blood - 22 Jul 2021

Morande Pablo Elías, Yan Xiao-Jie, Sepulveda Julieta, Seija Noé, Marquez María Elena, Sotelo Natalia, Abreu Cecilia, Crispo Martina, Fernández-Graña Gabriel, Rego Natalia, Bois Therence, Methot Stephen P, Palacios Florencia, Remedi Victoria, Rai Kanti R, Buschiazzo Alejandro, Di Noia Javier M, Navarrete Marcelo A, Chiorazzi Nicholas, Oppezzo Pablo

Abstract excerpt

Most cancers become more dangerous by the outgrowth of malignant subclones with additional DNA mutations that favor proliferation or survival. Using chronic lymphocytic leukemia (CLL), a disease that exemplifies this process and is a model for neoplasms in general, we created transgenic mice overexpressing the enzyme activation-induced deaminase (AID), which has a normal function of inducing DNA mutations in B...

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PMID: 34292322
DOI: 10.1182/blood.2020008654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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