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Article

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

PloS one - 21 Aug 2008

Hase Koji, Takahashi Daisuke, Ebisawa Masashi, Kawano Sayaka, Itoh Kikuji, Ohno Hiroshi

Abstract excerpt

Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR). Humans with AID mutations develop not only the autosomal recessive form of hyper-IgM syndrome (HIGM2) associated with B cell hyperplasia, but also autoimmune disorders by unknown mechanisms. We report here that AID-/- mice spontaneously...

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Identifiers

PMID: 18716662
DOI: 10.1371/journal.pone.0003033
PMCID: PMC2515643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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