Article
Aberrant AID expression and human cancer development.
The international journal of biochemistry & cell biology - 1 Jan 2008
Marusawa Hiroyuki
Abstract excerpt
Cancer develops via a multistep process that occurs through the accumulation of somatic mutations of tumor-related genes that govern cell proliferation, regeneration, and apoptosis. The question how normal cells acquire the genetic changes that lead to malignant transformation is, however, unknown at present. Activation-induced cytidine deaminase (AID) produces immune-diversity by inducing somatic hypermutations...
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