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Article

AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice.

Oncogene - 7 Aug 2008

Nepal R M, Zaheen A, Basit W, Li L, Berger S A, Martin A

Abstract excerpt

DNA breaks caused by recombination-activating gene 1 (RAG1) and activation-induced cytidine deaminase (AID) induce c-myc/immunoglobulin (Ig) heavy chain chromosomal translocations and thereby stimulate lymphomagenesis. However, constitutive expression of c-myc alone is not sufficient to induce lymphomas. Because RAG1 and AID activity occurs outside of Ig genes, we assessed whether these enzymes provide the...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Immunoglobulin mu-Chains

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Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 18408759
DOI: 10.1038/onc.2008.111

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice.PMID 18408759Read ↗

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