Article
A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization.
Structure (London, England : 1993) - 7 Feb 2017
Thompson Peter M, Ramachandran Srinivas, Case Lindsay B, Tolbert Caitlin E, Tandon Arpit, Pershad Mihir, Dokholyan Nikolay V, Waterman Clare M, Campbell Sharon L
Abstract excerpt
Vinculin, a scaffolding protein that localizes to focal adhesions (FAs) and adherens junctions, links the actin cytoskeleton to the adhesive super-structure. While vinculin binds to a number of cytoskeletal proteins, it can also associate with phosphatidylinositol 4,5-bisphosphate (PIP2) to drive membrane association. To generate a structural model for PIP2-dependent interaction of vinculin with the lipid...
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