Article
Talin binding to integrin beta tails: a final common step in integrin activation.
Science (New York, N.Y.) - 3 Oct 2003
Tadokoro Seiji, Shattil Sanford J, Eto Koji, Tai Vera, Liddington Robert C, de Pereda Jose M, Ginsberg Mark H, Calderwood David A
Abstract excerpt
Control of integrin affinity for ligands (integrin activation) is essential for normal cell adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually mediated through the integrin beta subunit cytoplasmic tail and can be regulated by many different biochemical signaling pathways. We report that specific binding of the cytoskeletal protein talin to integrin beta subunit...
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