Article
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner.
Current biology : CB - 18 Feb 2013
Carisey Alex, Tsang Ricky, Greiner Alexandra M, Nijenhuis Nadja, Heath Nikki, Nazgiewicz Alicja, Kemkemer Ralf, Derby Brian, Spatz Joachim, Ballestrem Christoph
Abstract excerpt
BACKGROUND: Cells sense the extracellular environment using adhesion receptors (integrins) linked to the intracellular actin cytoskeleton through a complex network of regulatory proteins that, all together, form focal adhesions (FAs). The molecular basis of how these sensing units are regulated, how they are implicated in transducing mechanical stimuli, and how this leads to a spatiotemporal coordination of FAs...
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