Article
Structural basis of integrin activation by talin.
Cell - 12 Jan 2007
Wegener Kate L, Partridge Anthony W, Han Jaewon, Pickford Andrew R, Liddington Robert C, Ginsberg Mark H, Campbell Iain D
Abstract excerpt
Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between talin and the...
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