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Article

Talin and vinculin combine their activities to trigger actin assembly.

Nature communications - 3 Nov 2024

Wang Hong, Said Rayan, Nguyen-Vigouroux Clémence, Henriot Véronique, Gebhardt Peter, Pernier Julien, Grosse Robert, Le Clainche Christophe

Abstract excerpt

Focal adhesions (FAs) strengthen their link with the actin cytoskeleton to resist force. Talin-vinculin association could reinforce actin anchoring to FAs by controlling actin polymerization. However, the actin polymerization activity of the talin-vinculin complex is not known because it requires the reconstitution of the mechanical and biochemical activation steps that control the association of talin and...

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Actin Cytoskeleton
Actins
Focal Adhesions
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

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PMID: 39489770
DOI: 10.1038/s41467-024-53859-1
PMCID: PMC11532549

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Talin and vinculin combine their activities to trigger actin assembly.PMID 39489770Read ↗

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A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization.Semantic proximity Read ↗

A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions.Semantic proximity Read ↗

Role of vinculin in regulating focal adhesion turnover.Semantic proximity Read ↗

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.Semantic proximity Read ↗

Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments.Semantic proximity Read ↗

Tyrosine phosphorylation of vinculin at position 1065 modifies focal adhesion dynamics and cell tractions.Semantic proximity Read ↗

Talin binding to integrin beta tails: a final common step in integrin activation.Semantic proximity Read ↗

The adhesion GPCR VLGR1/ADGRV1 regulates focal adhesion turnover by controlling their assemblySemantic proximity Read ↗

Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signalingSemantic proximity Read ↗

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