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Article

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.

Nature cell biology - 1 Jul 2015

Case Lindsay B, Baird Michelle A, Shtengel Gleb, Campbell Sharon L, Hess Harald F, Davidson Michael W, Waterman Clare M

Abstract excerpt

Focal adhesions (FAs) link the extracellular matrix to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signalling. FAs have conserved nanoscale protein organization, suggesting that the position of proteins within FAs regulates their activity and function. Vinculin binds different FA proteins to mediate distinct cellular functions, but how vinculin's interactions are...

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Identifiers

PMID: 26053221
DOI: 10.1038/ncb3180
PMCID: PMC4490039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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